Article

Targeting the catalytic activity of HDAC1 in T cells protects against experimental autoimmune encephalomyelitis

2023-04-14

Abstract excerpt

Histone deacetylases are key epigenetic regulators that control T cell-mediated immunity. A T cell-specific deletion of Hdac1 (HDAC1 cKO ) protects mice against experimental autoimmune encephalomyelitis (EAE). However, it remains elusive whether inhibition of HDAC1 enzymatic activity, which could be achieved therapeutically by HDAC1 inhibitor treatment, is sufficient to block EAE induction. In order to address t...

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Literature Corpus work: c21a14b2-6c0b-5c4a-a1e6-d1aacdef2da1
DOI: 10.1101/2023.04.14.536700

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