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Article

Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.

The Journal of biological chemistry - 10 Aug 2012

She Kevin, Ferreira Joana S, Carvalho Ana Luisa, Craig Ann Marie

Abstract excerpt

Trafficking of NMDA receptors to the surface of neurons and to synapses is critical for proper brain function and activity-dependent plasticity. Recent evidence suggests that surface trafficking of other ionotropic glutamate receptors requires ligand binding for exit from the endoplasmic reticulum. Here, we show that glutamate binding to GluN2 is required for trafficking of NMDA receptors to the cell surface. We...

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Identifiers

PMID: 22740692
DOI: 10.1074/jbc.M112.345108
PMCID: PMC3431666

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Related research

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Research trail→

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Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.PMID 22740692Read ↗

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Distinct Regulation of Early Trafficking of the NMDA Receptors by the Ligand-Binding Domains of the GluN1 and GluN2A Subunits.Semantic proximity Read ↗

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Tyrosine phosphorylation regulates the endocytosis and surface expression of GluN3A-containing NMDA receptors.Semantic proximity Read ↗

Molecular determinants controlling NMDA receptor synaptic incorporation.Semantic proximity Read ↗

A new motif necessary and sufficient for stable localization of the delta2 glutamate receptors at postsynaptic spines.Semantic proximity Read ↗

A Rare Variant Identified Within the GluN2B C-Terminus in a Patient with Autism Affects NMDA Receptor Surface Expression and Spine Density.Semantic proximity Read ↗

The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2.Semantic proximity Read ↗

Role of the fourth membrane domain of the NR2B subunit in the assembly of the NMDA receptor.Semantic proximity Read ↗

The pathogenic S688Y mutation in the ligand-binding domain of the GluN1 subunit regulates the properties of NMDA receptors.Semantic proximity Read ↗

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit.Semantic proximity Read ↗

Specific pathogenic mutations in the M3 domain of the GluN1 subunit regulate the surface delivery and pharmacological sensitivity of NMDA receptors.Semantic proximity Read ↗

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