Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity

14 Apr 2009

Abstract excerpt

Increased eukaryotic translation initiation factor 4E (eIF4E) expression occurs in many cancers, and makes fundamental contributions to carcinogenesis by stimulating the expression of cancer-related genes at post-transcriptional levels. This key role is highlighted by the facts that eIF4E levels can predict prognosis, and that eIF4E is an established therapeutic target. However, eIF4E activity is a complex...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mast cells and histamine
Share to Monoclonal and Polyclonal Antibodies Research
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19367274
DOI: 10.1038/sj.bjc.6605044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activityPMID 19367274Read ↗

Eukaryotic translation initiation factor 4E (eIF4E) expression is associated with breast cancer tumor phenotype and predicts survival after anthracycline chemotherapy treatment.Semantic proximity Read ↗

Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancerSemantic proximity Read ↗

The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survivalSemantic proximity Read ↗

Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancerSemantic proximity Read ↗

Genetic evidence supporting potential causal roles of EIF4 family in breast cancer: a two-sample randomized Mendelian study.Semantic proximity Read ↗

Robust eIF4B levels undermine invasive growth and immune evasion mechanisms in murine triple negative breast cancer modelsSemantic proximity Read ↗

Inhibiting the MNK-eIF4E-β-catenin axis increases the responsiveness of aggressive breast cancer cells to chemotherapy.Semantic proximity Read ↗

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells.Semantic proximity Read ↗

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer TherapySemantic proximity Read ↗

A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast CancerSemantic proximity Read ↗

Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissuesSemantic proximity Read ↗

4E-BP1, a multifactor regulated multifunctional proteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.