Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 13 Nov 2012

Sasidharan Nikhil, Sumakovic Marija, Hannemann Mandy, Hegermann Jan, Liewald Jana F, Olendrowitz Christian, Koenig Sabine, Grant Barth D, Rizzoli Silvio O, Gottschalk Alexander, Eimer Stefan

Abstract excerpt

Neurons secrete neuropeptides from dense core vesicles (DCVs) to modulate neuronal activity. Little is known about how neurons manage to differentially regulate the release of synaptic vesicles (SVs) and DCVs. To analyze this, we screened all Caenorhabditis elegans Rab GTPases and Tre2/Bub2/Cdc16 (TBC) domain containing GTPase-activating proteins (GAPs) for defects in DCV release from C. elegans motoneurons....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endosomes
Share to Exocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Golgi Apparatus

Share to Motor Neurons

Share to Neuropeptides

Share to rab GTP-Binding Proteins

Share to Secretory Vesicles

Share to Vesicular Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23100538
DOI: 10.1073/pnas.1203306109
PMCID: PMC3503202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans.PMID 23100538Read ↗

Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2.Semantic proximity Read ↗

UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans.Semantic proximity Read ↗

Two Rab2 interactors regulate dense-core vesicle maturation.Semantic proximity Read ↗

Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans.Semantic proximity Read ↗

The JIP3 scaffold protein UNC-16 regulates RAB-5 dependent membrane trafficking at C. elegans synapses.Semantic proximity Read ↗

Distinct Rab11-associated membrane trafficking pathways bidirectionally control neuronal extracellular vesicle cargo trafficSemantic proximity Read ↗

Rabx-5 regulates RAB-5 early endosomal compartments and synaptic vesicles in C. elegans.Semantic proximity Read ↗

RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits.Semantic proximity Read ↗

Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density.Semantic proximity Read ↗

CED-10/Rac1 regulates endocytic recycling through the RAB-5 GAP TBC-2.Semantic proximity Read ↗

RIC-7 promotes neuropeptide secretion.Semantic proximity Read ↗

Clathrin interaction and subcellular localization of Ce-DAB-1, an adaptor for protein secretion in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.