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Article

SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage.

The EMBO journal - 28 Nov 2012

Lee Seong Won, Lee Moon Hee, Park Jong Ho, Kang Sung Hwan, Yoo Hee Min, Ka Seung Hyun, Oh Young Mi, Jeon Young Joo, Chung Chin Ha

Abstract excerpt

Heterogeneous ribonucleoprotein-K (hnRNP-K) is normally ubiquitinated by HDM2 for proteasome-mediated degradation. Under DNA-damage conditions, hnRNP-K is transiently stabilized and serves as a transcriptional co-activator of p53 for cell-cycle arrest. However, how the stability and function of hnRNP-K is regulated remained unknown. Here, we demonstrated that UV-induced SUMOylation of hnRNP-K prevents its...

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Source

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Identifiers

PMID: 23092970
DOI: 10.1038/emboj.2012.293
PMCID: PMC3512394

Genes

PIAS3
SENP2
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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