Article
RB stabilizes XPC and promotes cellular NER.
Anticancer research - 1 Jul 2010
Hardy Tabitha M, Kumar Ma Suresh, Smith Martin L
Abstract excerpt
It has long been thought that the G(1)/S cell cycle checkpoint allows time for DNA repair by delaying S-phase entry. The p53 tumor suppressor pathway regulates the G(1)/S checkpoint by regulating the cyclin-dependent kinase inhibitor p21(Waf1/Cip1), but p53 also regulates the nucleotide excision DNA repair protein XPC. Here, using p53-null cell lines we show that additional mechanisms stabilize XPC protein and...
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