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Article

Comparison of statistical tests for disease association with rare variants.

Genetic epidemiology - 1 Nov 2011

Basu Saonli, Pan Wei

Abstract excerpt

In anticipation of the availability of next-generation sequencing data, there is increasing interest in investigating association between complex traits and rare variants (RVs). In contrast to association studies for common variants (CVs), due to the low frequencies of RVs, common wisdom suggests that existing statistical tests for CVs might not work, motivating the recent development of several new tests for...

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PMID: 21769936
DOI: 10.1002/gepi.20609
PMCID: PMC3197766

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