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Article

Integrative analysis of sequencing and array genotype data for discovering disease associations with rare mutations.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jan 2015

Hu Yi-Juan, Li Yun, Auer Paul L, Lin Dan-Yu

Abstract excerpt

In the large cohorts that have been used for genome-wide association studies (GWAS), it is prohibitively expensive to sequence all cohort members. A cost-effective strategy is to sequence subjects with extreme values of quantitative traits or those with specific diseases. By imputing the sequencing data from the GWAS data for the cohort members who are not selected for sequencing, one can dramatically increase...

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Identifiers

PMID: 25583502
DOI: 10.1073/pnas.1406143112
PMCID: PMC4313847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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