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Article

Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine.

Microbial cell factories - 24 Oct 2012

Peifer Susanne, Barduhn Tobias, Zimmet Sarah, Volmer Dietrich A, Heinzle Elmar, Schneider Konstantin

Abstract excerpt

BACKGROUND: Purine nucleotides exhibit various functions in cellular metabolism. Besides serving as building blocks for nucleic acid synthesis, they participate in signaling pathways and energy metabolism. Further, IMP and GMP represent industrially relevant biotechnological products used as flavor enhancing additives in food industry. Therefore, this work aimed towards the accumulation of IMP applying targeted...

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Identifiers

PMID: 23092390
DOI: 10.1186/1475-2859-11-138
PMCID: PMC3538647

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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