Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accumulation of gene-targeted Bacillus subtilis mutations that enhance fermentative inosine production.

Applied microbiology and biotechnology - 1 Aug 2010

Asahara Takayuki, Mori Yukiko, Zakataeva Natalia P, Livshits Vitaliy A, Yoshida Ken-ichi, Matsuno Kiyoshi

Abstract excerpt

In order to test a possible approach to enhance fermentative inosine production by Bacillus subtilis, seven gene-targeted mutations were introduced in the laboratory standard strain168 in a stepwise fashion. The mutations were employed in order to prevent inosine 5'-monophosphate (IMP) from being consumed for AMP and GMP synthesis, to minimize inosine degradation, and to expand the intracellular IMP pool. First,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacillus subtilis
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fermentation

Share to Gene Silencing

Share to Gene Targeting

Share to IMP Dehydrogenase

Share to Inosine

Share to Purine-Nucleoside Phosphorylase

Source

Identifiers

PMID: 20524113
DOI: 10.1007/s00253-010-2646-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accumulation of gene-targeted Bacillus subtilis mutations that enhance fermentative inosine production.PMID 20524113Read ↗

De novo engineering and metabolic flux analysis of inosine biosynthesis in Bacillus subtilis.Semantic proximity Read ↗

Nucleotide mutations in purA gene and pur operon promoter discovered in guanosine- and inosine-producing Bacillus subtilis strains.Semantic proximity Read ↗

Deregulation of purine pathway in Bacillus subtilis and its use in riboflavin biosynthesis.Semantic proximity Read ↗

Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine.Semantic proximity Read ↗

Definition of a second Bacillus subtilis pur regulon comprising the pur and xpt-pbuX operons plus pbuG, nupG (yxjA), and pbuE (ydhL).Semantic proximity Read ↗

High-Level 5-Methyltetrahydrofolate Bioproduction in Bacillus subtilis by Combining Modular Engineering and Transcriptomics-Guided Global Metabolic RegulationSemantic proximity Read ↗

Systems metabolic engineering of Bacillus subtilis for efficient biosynthesis of 5‐methyltetrahydrofolateSemantic proximity Read ↗

Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria.Semantic proximity Read ↗

Investigation of various genotype characteristics for inosine accumulation in Escherichia coli W3110.Semantic proximity Read ↗

gsk disruption leads to guanosine accumulation in Escherichia coli.Semantic proximity Read ↗

Role of Ribonucleotide Reductase in Bacillus subtilis Stress-Associated Mutagenesis.Semantic proximity Read ↗

[A new pleiotropic mutation affecting purine metabolism, sporulation and biosynthesis of exoenzymes in Bacillus subtilis].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.