Article
Targeted genomic sequencing of pediatric Burkitt lymphoma identifies recurrent alterations in antiapoptotic and chromatin-remodeling genes.
Blood - 20 Dec 2012
Giulino-Roth Lisa, Wang Kai, MacDonald Theresa Y, Mathew Susan, Tam Yifang, Cronin Maureen T, Palmer Gary, Lucena-Silva Norma, Pedrosa Francisco, Pedrosa Marcia, Teruya-Feldstein Julie, Bhagat Govind, Alobeid Bachir, Leoncini Lorenzo, Bellan Cristiana, Rogena Emily, Pinkney Kerice A, Rubin Mark A, Ribeiro Raul C, Yelensky Roman, Tam Wayne, Stephens Philip J, Cesarman Ethel
Abstract excerpt
To ascertain the genetic basis of pediatric Burkitt lymphoma (pBL), we performed clinical-grade next-generation sequencing of 182 cancer-related genes on 29 formalin-fixed, paraffin embedded primary pBL samples. Ninety percent of cases had at least one mutation or genetic alteration, most commonly involving MYC and TP53. EBV(-) cases were more likely than EBV(+) cases to have multiple mutations (P < .0001)....
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