Molecular distinctions between pediatric and adult mature B-cell non-Hodgkin lymphomas identified through genomic profiling.

doi:10.1182/blood-2011-05-349662

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Article

Molecular distinctions between pediatric and adult mature B-cell non-Hodgkin lymphomas identified through genomic profiling.

Blood - 19 Apr 2012

Deffenbacher Karen E, Iqbal Javeed, Sanger Warren, Shen Yulei, Lachel Cynthia, Liu Zhongfeng, Liu Yanyan, Lim Megan S, Perkins Sherrie L, Fu Kai, Smith Lynette, Lynch James, Staudt Louis M, Rimsza Lisa M, Jaffe Elaine, Rosenwald Andreas, Ott German K, Delabie Jan, Campo Elias, Gascoyne Randy D, Cairo Mitchell S, Weisenburger Dennis D, Greiner Timothy C, Gross Thomas G, Chan Wing C

Abstract excerpt

Burkitt lymphoma (BL) predominates in pediatric patients, whereas diffuse large B-cell lymphoma (DLBCL) is uncommon. In contrast to adults, BL and DLBCL are treated similarly in children and both entities have superior outcomes in children compared with adults. Gene expression profiling (GEP) and miRNA expression profiling clearly differentiated pediatric DLBCL from BL, forming distinct clusters regardless of...

Topics

Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Burkitt Lymphoma
Child
Child, Preschool
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Dosage

Gene Expression Profiling

Gene Rearrangement

Genomics

Humans

Loss of Heterozygosity

Lymphoma, Large B-Cell, Diffuse

Lymphoma, Non-Hodgkin

Male

Source

Open in PubMed Open full text

Identifiers

PMID: 22374697
DOI: 10.1182/blood-2011-05-349662
PMCID: PMC3335381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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