Article
FtsH (HflB) is an ATP-dependent protease selectively acting on SecY and some other membrane proteins.
The Journal of biological chemistry - 6 Dec 1996
Akiyama Y, Kihara A, Tokuda H, Ito K
Abstract excerpt
The FtsH protein is a membrane-bound ATPase of Escherichia coli that was proposed to be involved in membrane protein assembly as well as degradation of some unstable proteins. SecY, a subunit of protein translocase, is FtsH dependently degraded in vivo when it fails to associate with its partner (the SecE protein). We constructed a series of mutants in which mutations were introduced into conserved residues in...
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