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Article

Protein quality control and regulated proteolysis in the genome-reduced organism Mycoplasma pneumoniae.

Molecular systems biology - 1 Dec 2020

Burgos Raul, Weber Marc, Martinez Sira, Lluch-Senar Maria, Serrano Luis

Abstract excerpt

Protein degradation is a crucial cellular process in all-living systems. Here, using Mycoplasma pneumoniae as a model organism, we defined the minimal protein degradation machinery required to maintain proteome homeostasis. Then, we conditionally depleted the two essential ATP-dependent proteases. Whereas depletion of Lon results in increased protein aggregation and decreased heat tolerance, FtsH depletion...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33320415
DOI: 10.15252/msb.20209530
PMCID: PMC7737663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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