Article
Attenuated stress-evoked anxiety, increased sucrose preference and delayed spatial learning in glucocorticoid-induced receptor-deficient mice.
Genes, brain, and behavior - 1 Mar 2013
E Vollmer L, Ghosal S, A Rush J, R Sallee F, P Herman J, Weinert M, Sah R
Abstract excerpt
The glucocorticoid-induced receptor (GIR) is a stress-responsive gene that is abundantly expressed in forebrain limbic regions. Glucocorticoid-induced receptor has been classified as a Neuropeptide Y-like receptor, however, physiological attributes have not been investigated. In this study, mice lacking GIR (-/-) were screened in various paradigms related to stress, anxiety, activity, memory, fear and reward. GIR...
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