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Human Mismatch Repair Protein hMutLα Is Required to Repair Short Slipped-DNAs of Trinucleotide Repeats

20 Oct 2012

Abstract excerpt

Mismatch repair (MMR) is required for proper maintenance of the genome by protecting against mutations. The mismatch repair system has also been implicated as a driver of certain mutations, including disease-associated trinucleotide repeat instability. We recently revealed a requirement of hMutSβ in the repair of short slip-outs containing a single CTG repeat unit (1). The involvement of other MMR proteins in...

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PMID: 23086927
DOI: 10.1074/jbc.m112.420398

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Research trail→

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Human Mismatch Repair Protein hMutLα Is Required to Repair Short Slipped-DNAs of Trinucleotide RepeatsPMID 23086927Read ↗

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Mutations within the hMLH1 and hPMS2 subunits of the human MutLalpha mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSalpha.Semantic proximity Read ↗

Identification of hMutLβ, a Heterodimer of hMLH1 and hPMS1Semantic proximity Read ↗

The Interaction of DNA Mismatch Repair Proteins with Human Exonuclease ISemantic proximity Read ↗

ATM-Mediated Stabilization of hMutL DNA Mismatch Repair Proteins Augments p53 Activation during DNA DamageSemantic proximity Read ↗

MutSβ Stimulates Holliday Junction Resolution by the SMX ComplexSemantic proximity Read ↗

Slipped (CTG)*(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair.Semantic proximity Read ↗

Effects of the loss of mismatch repair genes on single-strand annealing between divergent sequences in Saccharomyces cerevisiae.Semantic proximity Read ↗

hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damageSemantic proximity Read ↗

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