DNA Triplet Repeat Expansion and Mismatch Repair

doi:10.1146/annurev-biochem-060614-034010

Article

DNA Triplet Repeat Expansion and Mismatch Repair

12 Jan 2015

Abstract excerpt

DNA mismatch repair is a conserved antimutagenic pathway that maintains genomic stability through rectification of DNA replication errors and attenuation of chromosomal rearrangements. Paradoxically, mutagenic action of mismatch repair has been implicated as a cause of triplet repeat expansions that cause neurological diseases such as Huntington disease and myotonic dystrophy. This mutagenic process requires the...

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