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N-terminus of hMLH1 confers interaction of hMutL and hMutL with hMutS

10 Jun 2003

Abstract excerpt

Mismatch repair is a highly conserved system that ensures replication fidelity by repairing mispairs after DNA synthesis. In humans, the two protein heterodimers hMutSalpha (hMSH2-hMSH6) and hMutLalpha (hMLH1-hPMS2) constitute the centre of the repair reaction. After recognising a DNA replication error, hMutSalpha recruits hMutLalpha, which then is thought to transduce the repair signal to the excision machinery....

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PMID: 12799449
DOI: 10.1093/nar/gkg420

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