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Article

Identification of hMutLβ, a Heterodimer of hMLH1 and hPMS1

1 Nov 1999

Abstract excerpt

hMLH1 and hPMS2 function in postreplicative mismatch repair in the form of a heterodimer referred to as hMutLalpha. Tumors or cell lines lacking this factor display mutator phenotypes and microsatellite instability, and mutations in the hMLH1 and hPMS2 genes predispose to hereditary non-polyposis colon cancer. A third MutL homologue, hPMS1, has also been reported to be mutated in one cancer-prone kindred, but the...

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Identifiers

PMID: 10542278
DOI: 10.1074/jbc.274.45.32368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of hMutLβ, a Heterodimer of hMLH1 and hPMS1PMID 10542278Read ↗

N-terminus of hMLH1 confers interaction of hMutL and hMutL with hMutSSemantic proximity Read ↗

Expression of the MutL Homologue hMLH3 in Human Cells and its Role in DNA Mismatch RepairSemantic proximity Read ↗

Mutations within the hMLH1 and hPMS2 subunits of the human MutLalpha mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSalpha.Semantic proximity Read ↗

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.Semantic proximity Read ↗

ATM-Mediated Stabilization of hMutL DNA Mismatch Repair Proteins Augments p53 Activation during DNA DamageSemantic proximity Read ↗

Human Mismatch Repair Protein hMutLα Is Required to Repair Short Slipped-DNAs of Trinucleotide RepeatsSemantic proximity Read ↗

Human mismatch-repair protein MutL homologue 1 (MLH1) interacts with Escherichia coli MutL and MutS in vivo and in vitro: a simple genetic system to assay MLH1 function.Semantic proximity Read ↗

The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts.Semantic proximity Read ↗

Mutations and loss of expression of a mismatch repair gene, hMLH1, in leukemia and lymphoma cell lines.Semantic proximity Read ↗

The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2Semantic proximity Read ↗

Genomic structure of human mismatch repair gene, hMLH1, and its mutation analysis in patients with hereditary non-polyposis colorectal cancer (HNPCC)Semantic proximity Read ↗

Isolation of MutSβ from Human Cells and Comparison of the Mismatch Repair Specificities of MutSβ and MutSαSemantic proximity Read ↗

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