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Article

Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue.

The Journal of biological chemistry - 25 May 2001

Habelhah H, Shah K, Huang L, Burlingame A L, Shokat K M, Ronai Z

Abstract excerpt

Modification of the ATP pocket on protein kinases allows selective use of an ATP analogue that exhibits high affinity for the altered kinases. Using this approach, we altered the ATP-binding site on JNK and identified N(6)-(2-phenythyl)-ATP, a modified form of ATP that exhibits high specificity a...

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Source

Identifiers

PMID: 11259409
DOI: 10.1074/jbc.M011396200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11259409-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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