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Article

Contribution of SUMO-interacting motifs and SUMOylation to the antiretroviral properties of TRIM5α.

Virology - 20 Jan 2013

Brandariz-Nuñez Alberto, Roa Amanda, Valle-Casuso Jose Carlos, Biris Nikolaos, Ivanov Dmitri, Diaz-Griffero Felipe

Abstract excerpt

Recent findings suggested that the SUMO-interacting motifs (SIMs) present in the human TRIM5α (TRIM5α(hu)) protein play an important role in the ability of TRIM5α(hu) to restrict N-MLV. Here we explored the role of SIMs in the ability of rhesus TRIM5α (TRIM5α(rh)) to restrict HIV-1, and found that TRIM5α(rh) SIM mutants IL376KK (SIM1mut) and VI405KK (SIM2mut) completely lost their ability to block HIV-1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23084420
DOI: 10.1016/j.virol.2012.09.042
PMCID: PMC3534947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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