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Article

Contribution of RING domain to retrovirus restriction by TRIM5alpha depends on combination of host and virus.

Virology - 10 Apr 2010

Maegawa Hikoichiro, Miyamoto Tadashi, Sakuragi Jun-Ichi, Shioda Tatsuo, Nakayama Emi E

Abstract excerpt

The anti-retroviral restriction factor TRIM5alpha contains the RING domain, which is frequently observed in E3 ubiquitin ligases. It was previously proposed that TRIM5alpha restricts human immunodeficiency virus type 1 (HIV-1) via proteasome-dependent and -independent pathways. Here we examined the effects of RING domain mutations on retrovirus restriction by TRIM5alpha in various combinations of virus and host...

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Identifiers

PMID: 20110098
DOI: 10.1016/j.virol.2010.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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