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Article

Contribution of E3-Ubiquitin Ligase Activity to HIV-1 Restriction by TRIM5α rh : Structure of the RING Domain of TRIM5α

7 Jul 2011

Abstract excerpt

TRIM5α(rh) is a cytosolic protein that potently restricts HIV-1 before reverse transcription. TRIM5α(rh) is composed of four different domains: RING, B-box 2, coiled coil, and B30.2(SPRY). The contribution of each of these domains to restriction has been extensively studied, with the exception of the RING domain. The RING domain of TRIM5α exhibits E3-ubiquitin ligase activity, but the contribution of this...

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Identifiers

PMID: 21734049
DOI: 10.1128/jvi.00497-11

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