Article
Rhesus monkey TRIM5α has distinct HIV-1 restriction activity among different mammalian cell lines.
Current microbiology - 1 Dec 2011
Gong Jian, Shen Xi-Hui, Qiu Hui, Chen Chao, Yang Rong-Ge
Abstract excerpt
Rhesus monkey TRIM5α (TRIM5α(rh)), a member of the tripartite motif (TRIM) family, was identified as the main restriction factor responsible for resistance of old world monkey cells to HIV-1 infection. However, the precise mechanism of HIV-1 infection inhibition by TRIM5α remains elusive and appears to be related to some cellular cofactors. Here we reported that TRIM5α(rh) can significantly reduce the infection...
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