Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans.

doi:10.1016/j.ajhg.2012.08.026

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Article

Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans.

American journal of human genetics - 2 Nov 2012

Morris David L, Taylor Kimberly E, Fernando Michelle M A, Nititham Joanne, Alarcón-Riquelme Marta E, Barcellos Lisa F, Behrens Timothy W, Cotsapas Chris, Gaffney Patrick M, Graham Robert R, Pons-Estel Bernardo A, Gregersen Peter K, Harley John B, Hauser Stephen L, Hom Geoffrey, Langefeld Carl D, Noble Janelle A, Rioux John D, Seldin Michael F, Criswell Lindsey A, Vyse Timothy J

Abstract excerpt

We have performed a meta-analysis of the major-histocompatibility-complex (MHC) region in systemic lupus erythematosus (SLE) to determine the association with both SNPs and classical human-leukocyte-antigen (HLA) alleles. More specifically, we combined results from six studies and well-known out-of-study control data sets, providing us with 3,701 independent SLE cases and 12,110 independent controls of European...

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Identifiers

PMID: 23084292
DOI: 10.1016/j.ajhg.2012.08.026
PMCID: PMC3487133

Genes

MICB
NOTCH4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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