Article
Patients with low HDL-cholesterol caused by mutations in LCAT have increased arterial stiffness.
Atherosclerosis - 1 Dec 2012
van den Bogaard Bas, Holleboom Adriaan G, Duivenvoorden Raphaël, Hutten Barbara A, Kastelein John J P, Hovingh G Kees, Kuivenhoven Jan Albert, Stroes Erik S G, van den Born Bert-Jan H
Abstract excerpt
OBJECTIVE: Carriers of a functional mutation in LCAT, encoding lecithin:cholesterol acyl transferase, are exposed to lifelong low high-density lipoprotein cholesterol (HDL-c) levels. We investigated whether LCAT mutation carriers have increased arterial stiffness as a marker of cardiovascular disease and whether arterial stiffness was associated with carotid wall thickening. METHODS: We assessed 45 carriers of...
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