Article
Compromised LCAT function is associated with increased atherosclerosis.
Circulation - 9 Aug 2005
Hovingh G Kees, Hutten Barbara A, Holleboom Adriaan G, Petersen Wilma, Rol Patrick, Stalenhoef Anton, Zwinderman Aeilko H, de Groot Eric, Kastelein John J P, Kuivenhoven Jan Albert
Abstract excerpt
BACKGROUND: Prospective epidemiological studies have shown that low plasma levels of HDL cholesterol (HDL-C) are associated with an increased risk for cardiovascular disease (CVD). Despite nearly 40 years of research, however, it is unclear whether this also holds true for individuals with severely reduced levels of HDL-C due to mutations in the lecithin:cholesterol acyltransferase (LCAT) gene. Better insight...
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