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Article

PERK-ing up autophagy during MYC-induced tumorigenesis

7 Mar 2013

Abstract excerpt

Stress in the tumor microenvironment in the form of hypoxia and low glucose/amino acid levels activates the evolutionarily conserved cellular adaptation program called the unfolded protein response (UPR) promoting cell survival in such conditions. Our recent studies showed that cell autonomous stress such as activation of the proto-oncogene MYC/c-Myc, can also trigger the UPR and induce endoplasmic reticulum (ER)...

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Autophagy in Disease and Therapy
Biochemical and Molecular Research
Endoplasmic Reticulum Stress and Disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23328692
DOI: 10.4161/auto.23486

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