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Article

Targeting XBP-1 as a novel anti-cancer strategy

1 Jul 2006

Abstract excerpt

The survival and growth of tumor cells within the microenvironment of a solid tumor necessitates the adaptation of these cells to ER stress. Hypoxia, in the context of the tumor microenvironment, is a critical ER stress that activates the unfolded protein response (UPR). This review focuses on the role of the IRE1-XBP1 branch of the UPR and its role in mediating cell survival and tumor growth. Inhibition of this...

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Identifiers

PMID: 16861911
DOI: 10.4161/cbt.5.7.2973

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