Article

STAT3 regulates the generation of astroglia in human brain organoids with high mTORC1 activity

2023-12-22

Abstract excerpt

During brain development, neural progenitor cells first produce neurons, then astrocytes and other glial cell types, which provide important trophic support and shape neuronal development and function. Intrinsic genetic programs interact with extracellular signals to control progenitor fate, resulting in temporally segregated periods of neurogenesis and gliogenesis. Animal models have implicated STAT3 as an import...

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Literature Corpus work: 212822f5-8615-5fbc-b7b4-3887cc299165
DOI: 10.1101/2023.12.21.572786

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