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Article

Loss of Tsc1 accelerates malignant gliomagenesis when combined with oncogenic signals.

Journal of biochemistry - 1 Apr 2014

Yamada Daisuke, Hoshii Takayuki, Tanaka Shingo, Hegazy Ahmed M, Kobayashi Masahiko, Tadokoro Yuko, Ohta Kumiko, Ueno Masaya, Ali Mohamed A E, Hirao Atsushi

Abstract excerpt

Glioblastomas frequently harbour genetic lesions that stimulate the activity of mammalian target of rapamycin complex 1 (mTORC1). Loss of heterozygosity of tuberous sclerosis complex 1 (TSC1) or TSC2, which together form a critical negative regulator of mTORC1, is also seen in glioblastoma; however, it is not known how loss of the TSC complex affects the development of malignant gliomas. Here we investigated the...

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Source

Identifiers

PMID: 24368778
DOI: 10.1093/jb/mvt112

Genes

EGFR
TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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