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Article

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2.

Nature - 22 Nov 2012

Liu Guang-Hui, Qu Jing, Suzuki Keiichiro, Nivet Emmanuel, Li Mo, Montserrat Nuria, Yi Fei, Xu Xiuling, Ruiz Sergio, Zhang Weiqi, Wagner Ulrich, Kim Audrey, Ren Bing, Li Ying, Goebl April, Kim Jessica, Soligalla Rupa Devi, Dubova Ilir, Thompson James, Yates John, Esteban Concepcion Rodriguez, Sancho-Martinez Ignacio, Izpisua Belmonte Juan Carlos

Abstract excerpt

Nuclear-architecture defects have been shown to correlate with the manifestation of a number of human diseases as well as ageing. It is therefore plausible that diseases whose manifestations correlate with ageing might be connected to the appearance of nuclear aberrations over time. We decided to evaluate nuclear organization in the context of ageing-associated disorders by focusing on a leucine-rich repeat...

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Source

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Identifiers

PMID: 23075850
DOI: 10.1038/nature11557
PMCID: PMC3504651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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