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Article

Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons.

Stem cell reports - 12 Dec 2017

Schwab Andrew J, Sison Samantha L, Meade Michael R, Broniowska Katarzyna A, Corbett John A, Ebert Allison D

Abstract excerpt

Mitochondrial changes have long been implicated in the pathogenesis of Parkinson's disease (PD). The glycine to serine mutation (G2019S) in leucine-rich repeat kinase 2 (LRRK2) is the most common genetic cause for PD and has been shown to impair mitochondrial function and morphology in multiple model systems. We analyzed mitochondrial function in LRRK2 G2019S induced pluripotent stem cell (iPSC)-derived neurons...

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Identifiers

PMID: 29129681
DOI: 10.1016/j.stemcr.2017.10.010
PMCID: PMC5785678

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