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Article

MicroRNA-10A* and MicroRNA-21 modulate endothelial progenitor cell senescence via suppressing high-mobility group A2.

Circulation research - 4 Jan 2013

Zhu Shoukang, Deng Shanming, Ma Qi, Zhang Taifang, Jia Chunling, Zhuo Degen, Yang Falin, Wei Jianqin, Wang Liyong, Dykxhoorn Derek M, Hare Joshua M, Goldschmidt-Clermont Pascal J, Dong Chunming

Abstract excerpt

RATIONALE: Endothelial progenitor cells (EPCs) contribute to the regeneration of endothelium. Aging-associated senescence results in reduced number and function of EPCs, potentially contributing to increased cardiac risk, reduced angiogenic capacity, and impaired cardiac repair effectiveness. The mechanisms underlying EPC senescence are unknown. Increasing evidence supports the role of microRNAs in regulating...

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Identifiers

PMID: 23072816
DOI: 10.1161/CIRCRESAHA.112.280016
PMCID: PMC3719009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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