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MicroRNA-21 Coordinates Human Multipotent Cardiovascular Progenitors Therapeutic Potential

28 Jul 2014

Abstract excerpt

Published clinical trials in patients with ischemic diseases show limited benefit of adult stem cell-based therapy, likely due to their restricted plasticity and commitment toward vascular cell lineage. We aim to uncover the potent regenerative ability of MesP1/stage-specific embryonic antigen 1 (SSEA-1)-expressing cardiovascular progenitors enriched from human embryonic stem cells (hESCs). Injection of only...

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PMID: 25069679
DOI: 10.1002/stem.1789

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