Article
High levels of oncomi R ‐21 contribute to the senescence‐induced growth arrest in normal human cells and its knock‐down increases the replicative lifespan
15 Mar 2013
Abstract excerpt
Cellular senescence of normal human cells has by now far exceeded its initial role as a model system for aging research. Many reports show the accumulation of senescent cells in vivo, their effect on their microenvironment and its double-edged role as tumour suppressor and promoter. Importantly, removal of senescent cells delays the onset of age-associated diseases in mouse model systems. To characterize the role...
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