Article
IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23.
Nature genetics - 1 Nov 2000
Gharavi A G, Yan Y, Scolari F, Schena F P, Frasca G M, Ghiggeri G M, Cooper K, Amoroso A, Viola B F, Battini G, Caridi G, Canova C, Farhi A, Subramanian V, Nelson-Williams C, Woodford S, Julian B A, Wyatt R J, Lifton R P
Abstract excerpt
End-stage renal disease (ESRD) is a major public health problem, affecting 1 in 1,000 individuals and with an annual death rate of 20% despite dialysis treatment. IgA nephropathy (IgAN) is the most common form of glomerulonephritis, a principal cause of ESRD worldwide; it affects up to 1.3% of the population and its pathogenesis is unknown. Kidneys of people with IgAN show deposits of IgA-containing immune...
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