Article
Absence of Foxp3+ regulatory T cells during allergen provocation does not exacerbate murine allergic airway inflammation.
PloS one - 1 Jan 2012
Baru Abdul Mannan, Ganesh Venkateswaran, Krishnaswamy Jayendra Kumar, Hesse Christina, Untucht Christopher, Glage Silke, Behrens Georg, Mayer Christian Thomas, Puttur Franz, Sparwasser Tim
Abstract excerpt
Regulatory T cells (Tregs) play a non-redundant role in maintenance of immune homeostasis. This is achieved by suppressing both, priming of naïve cells and effector cell functions. Although Tregs have been implicated in modulating allergic immune responses, their influence on distinct phases of development of allergies remains unclear. In this study, by using bacterial artificial chromosome (BAC)-transgenic...
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