Article
Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation.
Immunity - 18 Jul 2008
Curotto de Lafaille Maria A, Kutchukhidze Nino, Shen Shiqian, Ding Yi, Yee Herman, Lafaille Juan J
Abstract excerpt
Adaptive Foxp3(+) regulatory T (Treg) cells develop during induction of mucosal tolerance and after immunization. Large numbers of Foxp3(+) T cells have been found in inflamed tissues. We investigated the role of adaptive Foxp3(+) Treg cells in mucosal tolerance and in chronic allergic lung inflammation. We used two strains of mice that are devoid of naturally occurring Treg cells; one is capable of generating...
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