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Article

Optimal isolation of functional Foxp3+ induced regulatory T cells using DEREG mice.

PloS one - 1 Jan 2012

Baru Abdul Mannan, Untucht Christopher, Ganesh Venkateswaran, Hesse Christina, Mayer Christian T, Sparwasser Tim

Abstract excerpt

Foxp3 reporter mice including DEREG (DEpletion of REGulatory T cells) mice have greatly helped in exploring the biology of Foxp3(+) Tregs. DEREG mice express a DTR-eGFP fusion protein under the control of a bacterial artificial chromosome (BAC)-encoded Foxp3 promoter, allowing the viable isolation and inducible depletion of Foxp3(+) Tregs. Adaptive Tregs differentiated in vitro to express Foxp3 (iTregs) are...

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PMID: 22957107
DOI: 10.1371/journal.pone.0044760
PMCID: PMC3434173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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