Article
Association between CYP17A1 rs3824755 and rs743572 gene polymorphisms and Alzheimer's disease in the Chinese Han population.
Neuroscience letters - 8 Apr 2016
Xie Li, Yan Huacheng, Shi Lei, Kong Yanying, Huang Mukun, Li Jian, Li Jin, Zheng Jiaqiang, Zhao Yongpan, Zhao Shujin
Abstract excerpt
The CYP17A1 gene encodes cytochrome P450c17α, an enzyme that catalyzes the formation of sex hormones, which have been linked to the pathogenesis of Alzheimer's disease (AD). An association between the CYP17A1 rs743572 single nucleotide polymorphism (SNP) and AD has been reported; however, the findings are controversial. In the present study, we investigated the association between rs743572 and another SNP,...
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