Article
A frequent Toll-like receptor 1 gene polymorphism affects NK- and T-cell IFN-γ production and is associated with Helicobacter pylori-induced gastric disease.
Helicobacter - 1 Feb 2013
Yang Chin-An, Scheibenbogen Carmen, Bauer Sandra, Kleinle Christoph, Wex Thomas, Bornschein Jan, Malfertheiner Peter, Hellmig Stephan, Schumann Ralf R, Hamann Lutz
Abstract excerpt
BACKGROUND: Helicobacter pylori infects approximately 50% of the world population. Among the infected individuals, only 10-20% develop peptic ulcers and <3% progress to gastric cancer (GC). Th1-predominant immune responses have been suggested to underlie H. pylori-induced gastric diseases. Howeve...
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