Inherited cardiomyopathies caused by troponin mutations.

doi:10.3969/j.issn.1671-5411.2013.01.014

Article

Inherited cardiomyopathies caused by troponin mutations.

1 Mar 2013

Abstract excerpt

Genetic investigations of cardiomyopathy in the recent two decades have revealed a large number of mutations in the genes encoding sarcomeric proteins as a cause of inherited hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), or restrictive cardiomyopathy (RCM). Most functional analyses of the effects of mutations on cardiac muscle contraction have revealed significant changes in the...

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