Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mechanism of action of Spi-B in the transcriptional activation of the interferon-α4 gene.

Biochemical and biophysical research communications - 30 Apr 2020

Miyazaki Ryo, Saiga Hiroyuki, Kato Takumi, Bakoshi Takamitsu, Senba Rina, Shintani An, Suzuki Makiko, Takao Kenjiro, Sasaki Izumi, Iizuka Akihiko, Sugiyama Masanaka, Iwami Nana, Fukuda-Ohta Yuri, Hemmi Hiroaki, Tanaka Takashi, Miyake Minoru, Kaisho Tsuneyasu, Hoshino Katsuaki

Abstract excerpt

Plasmacytoid dendritic cells (pDCs) are characterized by an exclusive expression of nucleic acid sensing Toll-like receptor 7 (TLR7) and TLR9, and production of high amounts of type I interferon (IFN) in response to TLR7/9 signaling. This function is crucial for both antiviral immunity and the pathogenesis of autoimmune diseases. An Ets family transcription factor, i.e., Spi-B (which is highly expressed in pDCs)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to E1A-Associated p300 Protein
Share to HEK293 Cells
Share to Interferon-alpha
Share to Mice
Share to Promoter Regions, Genetic
Share to Protein Binding
Share to Proto-Oncogene Proteins c-ets
Share to Transcriptional Activation

Source

Identifiers

PMID: 32111355
DOI: 10.1016/j.bbrc.2020.02.101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mechanism of action of Spi-B in the transcriptional activation of the interferon-α4 gene.PMID 32111355Read ↗

Spi-B is critical for plasmacytoid dendritic cell function and development.Semantic proximity Read ↗

IRF7: role and regulation in immunity and autoimmunitySemantic proximity Read ↗

SPI-C, a PU-box binding ETS protein expressed temporarily during B-cell development and in macrophages, contains an acidic transactivation domain located to the N-terminus.Semantic proximity Read ↗

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interactionSemantic proximity Read ↗

Regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signaling.Semantic proximity Read ↗

Mechanisms of transcriptional activation of the stimulator of interferon genes by transcription factors CREB and c-MycSemantic proximity Read ↗

Differential Regulation of Human Interferon A Gene Expression by Interferon Regulatory Factors 3 and 7Semantic proximity Read ↗

Non-transcriptional IRF7 interacts with NF-κB to inhibit viral inflammation.Semantic proximity Read ↗

Recruitment of Multiple Interferon Regulatory Factors and Histone Acetyltransferase to the Transcriptionally Active Interferon A PromotersSemantic proximity Read ↗

Antiviral Activity of Interferon Alpha-Inducible Protein 27 Against Hepatitis B Virus Gene Expression and ReplicationSemantic proximity Read ↗

The multi-target regulation of cytokine storm by transcription factor Blimp-1Semantic proximity Read ↗

Differential Expression and Distinct Functions of IFN Regulatory Factor 4 and IFN Consensus Sequence Binding Protein in MacrophagesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics