Article
A dominant-negative mutation of HSF2 associated with idiopathic azoospermia.
Human genetics - 1 Feb 2013
Mou Lisha, Wang Yadong, Li Honggang, Huang Yi, Jiang Tao, Huang Weiren, Li Zesong, Chen Jing, Xie Jun, Liu Yuchen, Jiang Zhimao, Li Xianxin, Ye Jiongxian, Cai Zhiming, Gui Yaoting
Abstract excerpt
Idiopathic azoospermia (IA) is a severe form of male infertility due to unknown causes. The HSF2 gene, encoding the heat shock transcription factor 2, had been suggested to play a significant role in the spermatogenesis process since the Hsf2-knockout male mice showed spermatogenesis defects. To examine whether HSF2 is involved in the pathogenesis of IA in human, we sequenced all the exons of HSF2 in 766 patients...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.