Article
Brain abnormalities, defective meiotic chromosome synapsis and female subfertility in HSF2 null mice.
The EMBO journal - 3 Jun 2002
Kallio Marko, Chang Yunhua, Manuel Martine, Alastalo Tero-Pekka, Rallu Murielle, Gitton Yorick, Pirkkala Lila, Loones Marie-Thérèse, Paslaru Liliana, Larney Severine, Hiard Sophie, Morange Michel, Sistonen Lea, Mezger Valérie
Abstract excerpt
Heat shock factor 2, one of the four vertebrate HSFs, transcriptional regulators of heat shock gene expression, is active during embryogenesis and spermatogenesis, with unknown functions and targets. By disrupting the Hsf2 gene, we show that, although the lack of HSF2 is not embryonic lethal, Hsf2(-/-) mice suffer from brain abnormalities, and meiotic and gameto genesis defects in both genders. The disturbances...
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