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Article

Novel biallelic HFM1 variants cause severe oligozoospermia with favorable intracytoplasmic sperm injection outcome.

Asian journal of andrology - 1 Nov 2025

Liu Liu, Zhou Yi-Ling, Tian Wei-Dong, Jiang Feng, Wang Jia-Xiong, Zhang Feng, Liu Chun-Yu, Zhu Hong

Abstract excerpt

ABSTRACT: Male factors contribute to 50% of infertility cases, with 20%-30% of cases being solely attributed to male infertility. Helicase for meiosis 1 ( HFM1 ) plays a crucial role in ensuring proper crossover formation and synapsis of homologous chromosomes during meiosis, an essential process in gametogenesis. HFM1 gene mutations are associated with male infertility, particularly in cases of non-obstructive...

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Exome Sequencing
Mutation
Oligospermia
Sperm Injections, Intracytoplasmic
Spermatozoa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40320820
DOI: 10.4103/aja20259
PMCID: PMC12637876

Genes

HFM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Novel biallelic HFM1 variants cause severe oligozoospermia with favorable intracytoplasmic sperm injection outcome.PMID 40320820Read ↗

Novel variants in helicase for meiosis 1 lead to male infertility due to non-obstructive azoospermiaSemantic proximity Read ↗

Novel Variants in HFM1 Lead to Male Infertility Due to Non-obstructive AzoospermiaSemantic proximity Read ↗

BiallelicHFM1variants cause non-obstructive azoospermia with meiotic arrest in humans by impairing crossover formation to varying degreesSemantic proximity Read ↗

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