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Article

A functional variant in the UBE2B gene promoter is associated with idiopathic azoospermia.

Reproductive biology and endocrinology : RB&E - 30 Jul 2015

Mou Lisha, Zhang Qiang, Diao Ruiying, Cai Zhiming, Gui Yaoting

Abstract excerpt

BACKGROUND: A variety of genetic variants lead to abnormal human spermatogenesis. The ubiquitin-conjugating enzyme E2B (UBE2B) plays a significant role in spermatogenesis as Ube2b-knockout male mice are infertile. METHODS: In this study, we sequenced the exon and promoter region of UBE2B in 776 patients diagnosed with idiopathic azoospermia (IA) and 709 proven fertile men to examine whether UBE2B is involved in...

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Identifiers

PMID: 26223869
DOI: 10.1186/s12958-015-0074-4
PMCID: PMC4520152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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