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Article

Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility.

Genesis (New York, N.Y. : 2000) - 1 Feb 2004

Wang Guanghu, Ying Zhekang, Jin Xiongjie, Tu Naxin, Zhang Yan, Phillips Michele, Moskophidis Demetrius, Mivechi Nahid F

Abstract excerpt

Heat shock factors (Hsfs) are major transactivators of heat shock proteins but are also involved in regulation of other genes active in embryonic development. High expression levels of Hsfs in mouse testis during development suggest a role for these factors in spermatogenesis, a cyclic process of spermatogonia cell-differentiation into mature spermatozoa. In contrast to hsf1(-/-) mice, which exhibit normal...

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PMID: 14994269
DOI: 10.1002/gene.20005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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