Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus.

Proceedings of the National Academy of Sciences of the United States of America - 30 Oct 2012

Freimuth Julia, Clermont Frederic F, Huang Xiaozhu, DeSapio Angela, Tokuyasu Taku A, Sheppard Dean, Akhurst Rosemary J

Abstract excerpt

TGFβ activation and signaling have been extensively studied in experimental models of allergen-induced asthma as potential therapeutic targets during chronic or acute phases of the disease. Outcomes of experimental manipulation of TGFβ activity have been variable, in part due to use of different model systems. Using an ovalbumin (OVA)-induced mouse model of asthma, we here show that innate variation within TGFβ1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to AHR gene

Share to Genetic Predisposition to Disease

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 23064636
DOI: 10.1073/pnas.1205374109
PMCID: PMC3497801

Genes

AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus.PMID 23064636Read ↗

TGFβ receptor mutations impose a strong predisposition for human allergic disease.Semantic proximity Read ↗

Airway Remodeling in Asthma: Therapeutic Implications of MechanismsSemantic proximity Read ↗

Epistatic interactions between modifier genes confer strain-specific redundancy for Tgfb1 in developmental angiogenesis.Semantic proximity Read ↗

The magnitude of airway remodelling is not altered by distinct allergic inflammatory responses in BALB/c vs C57BL/6 mice but matrix composition differsSemantic proximity Read ↗

Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility.Semantic proximity Read ↗

Transforming Growth Factor-β3 (TGF-β3) Knock-in Ameliorates Inflammation Due to TGF-β1 Deficiency While Promoting Glucose ToleranceSemantic proximity Read ↗

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation.Semantic proximity Read ↗

New Insights Into the Regulation of TGF-β/Smad and MPK Signaling Pathway Gene Expression by Nasal Allergen and Methacholine Challenge Test in Asthma.Semantic proximity Read ↗

TGF-β1 drives Th9 but not Treg cells upon allergen exposureSemantic proximity Read ↗

Variants in TGFB1, dust mite exposure, and disease severity in children with asthma.Semantic proximity Read ↗

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early lifeSemantic proximity Read ↗

MiR-365-3p is Involved in IL17-Mediated Asthma in Mouse ModelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.